Comparative genomic hybridization (CGH) is a fairly new molecular cytogenetic technique that allows detection of DNA sequence copy number changes throughout the genome in a single hybridization. CGH is based on co-hybridization of differentially labeled tumor and normal DNA to human metaphase chromosomes.
Monday,Jul 20,2009 Source: Molecular Profiling InitiativeDetailed procedures for lymphocyte isolation from blood, lymphocyte culture and micronucleus assay.
Monday,Jul 20,2009 Source: Nina T. Holland, Division of EAlpha satellite sequences, whilst highly repetitive, are specific to each individual chromosome. These sequences flank the centromeres and can present a target measured in megabases. In this protocol a biotin or digoxigenin labelled DNA probe is detec
Monday,Jul 20,2009 Source: Matt Lewis, Department of Path
